{"id":186,"date":"2021-02-04T10:58:07","date_gmt":"2021-02-04T09:58:07","guid":{"rendered":"http:\/\/127.0.0.1\/wordpress\/?page_id=186"},"modified":"2025-09-04T07:38:34","modified_gmt":"2025-09-04T05:38:34","slug":"rndr-ladislav-janovec-phd","status":"publish","type":"page","link":"https:\/\/organicchemistry.science.upjs.sk\/?page_id=186","title":{"rendered":"doc. RNDr. Ladislav Janovec, PhD."},"content":{"rendered":"\n<p><strong>Osobn\u00fd profil<\/strong> : <a rel=\"noreferrer noopener\" href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/ladislav.janovec\" target=\"_blank\">https:\/\/www.upjs.sk\/PF\/zamestnanec\/ladislav.janovec<\/a><\/p>\n\n\n\n<p>ladislav.janovec@upjs.sk<\/p>\n\n\n\n<p>Docent<\/p>\n\n\n\n<p><strong>V\u00fdskum<\/strong><\/p>\n\n\n\n<p>Synt\u00e9za deriv\u00e1tov akrid\u00ednu interaguj\u00facich s DNA G\u2013kvadruplexom s n\u00e1slednou inhib\u00edciou enz\u00fdmu telomer\u00e1za, ved\u00facou k&nbsp;zastaveniu zhubnej prolifer\u00e1cie.<\/p>\n\n\n\n<p>\u0160t\u00fadium DNA interkala\u010dn\u00fdch schopnost\u00ed deriv\u00e1tov akrid\u00ednu ako aj ich inhibi\u010dn\u00e9ho potenci\u00e1lu vo\u010di topoizomer\u00e1ze I \/ II s&nbsp;cie\u013eom ur\u010di\u0165 mieru vplyvu \u0161trukt\u00farnych zmien na cytotoxick\u00fa aktivitu.<\/p>\n\n\n\n<p>Vyu\u017eitie princ\u00edpov teoretickej ch\u00e9mie na objasnenie vplyvu zmeny \u0161trukt\u00fary syntetizovan\u00fdch deriv\u00e1tov akrid\u00ednu na antitumorov\u00fa aktivitu s&nbsp;cie\u013eom optimaliz\u00e1cie molekulov\u00e9ho dizajnu potenci\u00e1lnych chemoterapeutik na b\u00e1ze akrid\u00ednov\u00e9ho heterocyklu.<\/p>\n\n\n\n<p>2003 \u2013 2004 Postdoktorandk\u00fd &nbsp;pobyt na Univerzite Bayreuth v&nbsp;r\u00e1mci v\u00fdvoja a&nbsp;v\u00fdskumu Biochip technology.<\/p>\n\n\n\n<p><strong>Vyu\u010dovan\u00e9 predmety:<\/strong><\/p>\n\n\n\n<p>Zimn\u00fd semester<\/p>\n\n\n\n<ul><li><em>Informa\u010dn\u00e9 syst\u00e9my v&nbsp;ch\u00e9mii I<\/em><\/li><li><em>Kvantov\u00e1 ch\u00e9mia<\/em><\/li><li><em>Molekulov\u00fd modeling<\/em><\/li><\/ul>\n\n\n\n<p>Letn\u00fd semester<\/p>\n\n\n\n<ul><li><em>Informa\u010dn\u00e9 syst\u00e9my v&nbsp;ch\u00e9mii II<\/em><\/li><li><em>Modern\u00e9 syntetick\u00e9 met\u00f3dy<\/em><\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Osobn\u00fd profil : https:\/\/www.upjs.sk\/PF\/zamestnanec\/ladislav.janovec ladislav.janovec@upjs.sk Docent V\u00fdskum Synt\u00e9za deriv\u00e1tov akrid\u00ednu interaguj\u00facich s DNA G\u2013kvadruplexom s n\u00e1slednou inhib\u00edciou enz\u00fdmu telomer\u00e1za, ved\u00facou k&nbsp;zastaveniu zhubnej prolifer\u00e1cie. \u0160t\u00fadium DNA interkala\u010dn\u00fdch schopnost\u00ed deriv\u00e1tov akrid\u00ednu ako aj ich inhibi\u010dn\u00e9ho potenci\u00e1lu vo\u010di topoizomer\u00e1ze I \/ II s&nbsp;cie\u013eom ur\u010di\u0165 mieru vplyvu \u0161trukt\u00farnych zmien na cytotoxick\u00fa aktivitu. Vyu\u017eitie princ\u00edpov teoretickej ch\u00e9mie na objasnenie vplyvu &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/organicchemistry.science.upjs.sk\/?page_id=186\" class=\"more-link\">Pokra\u010dova\u0165 v \u010d\u00edtan\u00ed<span class=\"screen-reader-text\"> &#8222;doc. RNDr. Ladislav Janovec, PhD.&#8220;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages\/186"}],"collection":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=186"}],"version-history":[{"count":2,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages\/186\/revisions"}],"predecessor-version":[{"id":595,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages\/186\/revisions\/595"}],"wp:attachment":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}