{"id":263,"date":"2021-02-05T14:08:25","date_gmt":"2021-02-05T13:08:25","guid":{"rendered":"http:\/\/localhost\/wordpress\/?page_id=263"},"modified":"2021-08-02T12:53:35","modified_gmt":"2021-08-02T10:53:35","slug":"vybrane-publikacie","status":"publish","type":"page","link":"https:\/\/organicchemistry.science.upjs.sk\/?page_id=263","title":{"rendered":"V\u00fdznamn\u00e9 publik\u00e1cie"},"content":{"rendered":"\n

Hamulakova, S.; Janovec, L.; Soukup, O.; Jun, D.; Kuca, K.*<\/p>\n\n\n\n

Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids<\/em><\/p>\n\n\n\n

Int. J. Biolog. Macromol.<\/em> 2017<\/strong>, 104<\/em>, 333\u2012338<\/p>\n\n\n\n

IF: 5.162<\/em><\/p>\n\n\n\n

https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.06.006<\/a><\/p>\n\n\n\n

Abstrakt:<\/em> Bola pripraven\u00e1 nov\u00e1 s\u00e9ria akrid\u00edn-kumar\u00ednov\u00fdch hybridov, ktor\u00e9 boli testovan\u00e9 ako potenci\u00e1ln\u00e9 inhib\u00edtory enz\u00fdmov acetylchol\u00ednester\u00e1zy (AChE) and butyrylchol\u00ednester\u00e1zy (BuChE). Novo syntetizovan\u00e9 deriv\u00e1ty vykazovali vy\u0161\u0161iu inhibi\u010dn\u00fa \u00fa\u010dinnos\u0165 vo\u010di \u013eudskej AChE (h<\/em>AChE) v porovnan\u00ed so \u0161tandardom (7-MEOTA). Z tejto s\u00e9rie l\u00e1tok naj\u00fa\u010dinnej\u0161\u00edm inhib\u00edtorom h<\/em>AChE bol deriv\u00e1t 9b<\/strong> s hodnotou IC50<\/sub> = 5.85 \u03bcM (7-MEOTA: IC50<\/sub> = 15 \u03bcM). Na predikciu v\u00e4zbov\u00fdch  interakci\u00ed akrid\u00edn-kumar\u00ednov\u00fdch hybridov 9b<\/strong>, 9c<\/strong>, 9f<\/strong> s h<\/em>AChE\/BuChE bol uroben\u00fd molekulov\u00fd modeling.<\/p>\n\n\n\n

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Nunhart, P.; Konkolova, E.; Janovec, L.; Jendzelovsky, R.; Vargova, J.; Sevc, J.; Matejova, M.; Miltakova, B.; Fedorocko, P.; Kozurkova, M.*<\/p>\n\n\n\n

Fluorinated 3,6,9-trisubstituted acridine derivatives as DNA interacting agents and topoisomerase inhibitors with A549 antiproliferative activity<\/em><\/p>\n\n\n\n

Bioorganic Chemistry <\/em>2020<\/strong>, 94<\/em>, article number 103393<\/p>\n\n\n\n

IF: 4.831<\/p>\n\n\n\n

https:\/\/doi.org\/10.1016\/j.bioorg.2019.103393<\/a><\/p>\n\n\n\n

Abstrakt:<\/em> V\u00fdberom vhodn\u00fdch syntetick\u00fdch postupov sme pripravili z difenylmet\u00e1nu I<\/em><\/strong> trisubstituovan\u00e9 akrid\u00edny III <\/em><\/strong>\u2013 VI<\/em><\/strong>. Z\u00e1kladn\u00fdm medziproduktom v pr\u00edprave fin\u00e1lnych produktov bol akrid\u00f3n II<\/em><\/strong>. Pripraven\u00e9 zl\u00fa\u010deniny III <\/em><\/strong>\u2013 VI<\/em> <\/strong>sme n\u00e1sledne pou\u017eili na \u0161t\u00fadium ich DNA interkala\u010dn\u00fdch schopnost\u00ed a inhib\u00edcie enz\u00fdmu topoizomer\u00e1za I\/II.  Z\u00edskan\u00e9 akrid\u00edny III <\/em><\/strong>\u2013 VI<\/em><\/strong> vykazovali antiprolifera\u010dn\u00e9 vlastnosti, kde najvy\u0161\u0161iu inhibi\u010dn\u00fa aktivitu vo\u010di rakovinovej bunkovej l\u00edni\u00ed A549 mal deriv\u00e1t VI<\/em><\/strong> (IC<\/em>50<\/sub> = 4,25\u00d710-6<\/sup> M).<\/p>\n\n\n\n

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<\/p>\n\n\n\n

Budovsk\u00e1, M.<\/p>\n\n\n\n

A novel palladium-catalyzed cyclization of indole phytoalexin brassinin and its 1-substituted derivatives<\/em><\/p>\n\n\n\n

RSC Advances<\/em> 2014<\/strong>, 4, 5575-5582.<\/p>\n\n\n\n

IF: 3.119<\/p>\n\n\n\n

https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2014\/RA\/c3ra46843g#!divAbstract<\/a><\/p>\n\n\n\n

Abstrakt:<\/em> Nov\u00fd jednoduch\u00fd synetick\u00fd pr\u00edstup k spiroindol\u00ednov\u00fdm fytoalex\u00ednom a ich deriv\u00e1tov bol dosiahnut\u00fd spirocykliz\u00e1ciou brasin\u00ednu a jeho 1-substituovan\u00fdch deriv\u00e1tov pou\u017eit\u00edm pal\u00e1diov\u00e9ho katalyz\u00e1tora PdCl2<\/sub>(CH3<\/sub>CN)2<\/sub> v DMSO pri 80 \u00b0C v pr\u00edtomnosti vody, metanolu alebo anil\u00ednu.<\/p>\n\n\n\n

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<\/p>\n\n\n\n

\u0160pakov\u00e1 Raschmanov\u00e1, J.; Martinkov\u00e1, M.*; Gonda, J.; Bago Pil\u00e1tov\u00e1, M.; Kuch\u00e1r, J.; J\u00e1ger, D.<\/p>\n\n\n\n

Synthesis and in vitro biological evaluation of 3-amino-3-deoxydihydrosphingosines and their related analogues<\/em><\/p>\n\n\n\n

Tetrahedron<\/em> 2020<\/strong>, 76<\/em>, article number 130803<\/p>\n\n\n\n

https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040402019312074<\/a><\/p>\n\n\n\n

IF: 2.233  <\/p>\n\n\n\n

https:\/\/doi.org\/10.1016\/j.tet.2019.130803<\/a><\/p>\n\n\n\n

Abstrakt:<\/em> V uvedenej pr\u00e1ci je pop\u00edsan\u00e1 stereoselekt\u00edvna synt\u00e9za nezvy\u010dajn\u00fdch sfingoidn\u00fdch b\u00e1z na b\u00e1ze 3-amino-3-deoxydihydrosfingoz\u00ednov a ich izom\u00e9rnych anal\u00f3gov. Vypracovan\u00fd pr\u00edstup aplikoval klasick\u00fa chiral-pool<\/em> strat\u00e9giu s dimetylesterom kyseliny l-v\u00ednnej ako v\u00fdchodiskov\u00fdm chir\u00f3nom. Syntetick\u00fd pl\u00e1n vyu\u017eil atrib\u00faty [3,3]-sigmatropn\u00fdch pre\u0161mykov a olefin-cross<\/em> metat\u00e9zy ako k\u013e\u00fa\u010dov\u00fdch transform\u00e1ci\u00ed. Biologick\u00fd skr\u00edning cie\u013eov\u00fdch molek\u00fal odhalil ich pozoruhodn\u00fa antiprolifera\u010dn\u00fa\/cytotoxick\u00fa aktivitu na viacer\u00fdch hum\u00e1nnych rakovinov\u00fdch bunkov\u00fdch l\u00edniach.<\/p>\n\n\n\n

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Hamulakova, S.; Janovec, L.; Soukup, O.; Jun, D.; Kuca, K.* Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids Int. J. Biolog. Macromol. 2017, 104, 333\u2012338 IF: 5.162 https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.06.006 Abstrakt: Bola pripraven\u00e1 nov\u00e1 s\u00e9ria akrid\u00edn-kumar\u00ednov\u00fdch hybridov, ktor\u00e9 boli testovan\u00e9 ako potenci\u00e1ln\u00e9 inhib\u00edtory enz\u00fdmov acetylchol\u00ednester\u00e1zy (AChE) and butyrylchol\u00ednester\u00e1zy (BuChE). Novo syntetizovan\u00e9 deriv\u00e1ty … <\/p>\n

Pokra\u010dova\u0165 v \u010d\u00edtan\u00ed „V\u00fdznamn\u00e9 publik\u00e1cie“<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages\/263"}],"collection":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=263"}],"version-history":[{"count":3,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages\/263\/revisions"}],"predecessor-version":[{"id":544,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages\/263\/revisions\/544"}],"wp:attachment":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}