{"id":265,"date":"2021-02-05T14:08:25","date_gmt":"2021-02-05T13:08:25","guid":{"rendered":"http:\/\/localhost\/wordpress\/?page_id=265"},"modified":"2021-02-05T14:08:25","modified_gmt":"2021-02-05T13:08:25","slug":"projekty","status":"publish","type":"page","link":"https:\/\/organicchemistry.science.upjs.sk\/?page_id=265","title":{"rendered":"V\u00fdznamn\u00e9 projekty"},"content":{"rendered":"\n

VEGA 1\/0375\/19<\/strong><\/p>\n\n\n\n

N\u00e1zov projektu:<\/em> Stereoselekt\u00edvna synt\u00e9za fotoakt\u00edvnych molek\u00fal s pyrolid\u00ednov\u00fdmi farmakof\u00f3rmi na b\u00e1ze broussonet\u00ednov, oxazolomyc\u00ednov a laktacyst\u00ednu<\/strong><\/p>\n\n\n\n

Zodpovedn\u00fd rie\u0161ite\u013e:<\/em> RNDr. M\u00e1ria Vilkov\u00e1, PhD., doc. RNDr. Miroslava Martinkov\u00e1, PhD.<\/p>\n\n\n\n

Anot\u00e1cia projektu:<\/em><\/p>\n\n\n\n

Projekt sa zaober\u00e1 stereoselekt\u00edvnou synt\u00e9zou fotoakt\u00edvnych molek\u00fal so zabudovan\u00fdmi pyrolid\u00ednov\u00fdmi farmakof\u00f3rmi na b\u00e1ze boussonet\u00ednov, oxazolomyc\u00ednov a laktacyst\u00ednu. Inkorporovan\u00e9 azobenz\u00e9nov\u00e9 prep\u00edna\u010de a fotocitliv\u00e9 chr\u00e1niace skupiny umo\u017enia mo\u017enos\u0165 cielenej zmeny ich biologickej aktivity.<\/p>\n\n\n\n

VEGA 1\/0047\/18<\/strong><\/p>\n\n\n\n

N\u00e1zov projektu:<\/em> S<\/strong>tereokonvergentn\u00e1 synt\u00e9za izom\u00e9rnych sfingoidn\u00fdch b\u00e1z a pr\u00edbuzn\u00fdch \u201elong-chain\u201c aminoalkoholov ako potenci\u00e1lnych protirakovinov\u00fdch l\u00e1tok<\/strong><\/strong><\/p>\n\n\n\n

Zodpovedn\u00fd rie\u0161ite\u013e:<\/em> doc. RNDr. Miroslava Martinkov\u00e1, PhD.<\/p>\n\n\n\n

Anot\u00e1cia projektu:<\/em> Projekt sa venuje stereoselekt\u00edvnej synt\u00e9ze enantiom\u00e9rne \u010dist\u00fdch izom\u00e9rnych sfingoidn\u00fdch b\u00e1z a pr\u00edbuzn\u00fdch \u201elong-chain\u201c aminoalkoholov  a vyu\u017e\u00edva  kyselinu l-v\u00ednnu ako v\u00fdchodiskov\u00fd chir\u00f3n. So z\u00e1merom h\u013eadania \u00fa\u010dinnej protirakovinovej l\u00e1tky, bud\u00fa cie\u013eov\u00e9 \u0161trukt\u00fary podroben\u00e9 biologick\u00e9mu skr\u00edningu, ktor\u00fd bude s\u00fastreden\u00fd na predpokladan\u00fd antiprolifera\u010dn\u00fd\/cytotoxick\u00fd potenci\u00e1l. V\u00fdsledky testovania prines\u00fa cenn\u00e9 inform\u00e1cie predov\u0161etk\u00fdm do vz\u0165ahu \u0161trukt\u00fara-aktivita u pripraven\u00fdch l\u00e1tok a jednozna\u010dne roz\u0161\u00edria datab\u00e1zu predlohov\u00fdch \u0161trukt\u00far pre dizajnovanie molek\u00fal s protirakovinovou aktivitou, zalo\u017eenom predov\u0161etk\u00fdm na modulovan\u00ed metabolizmu sfingolipidov.<\/p>\n\n\n\n

<\/p>\n\n\n\n

N\u00e1zov projektu:<\/em> Otvoren\u00e1 vedeck\u00e1 komunita pre modern\u00fd interdisciplin\u00e1rny v\u00fdskum v medic\u00edne<\/strong> (OPENMED)<\/strong><\/p>\n\n\n\n

Opera\u010dn\u00fd program V\u00fdskum a inov\u00e1cie, Ministerstvo \u0161kolstva, vedy, v\u00fdskumu a \u0161portu SR: V\u00fdskumovo-v\u00fdvojov\u00fd z\u00e1mer projektu na podporu dlhodob\u00e9ho strategick\u00e9ho z\u00e1ujmu \u2013 Zdravie obyvate\u013estva a zdravotn\u00edcke technol\u00f3gie. K\u00f3d ITMS2014+: 313011V455.<\/p>\n\n\n\n

Aktivita<\/em>: \u201eV\u00fdvoj <\/em>inteligentn\u00fdch fotocitliv\u00fdch lie\u010div a nanop\u00f3rovit\u00fdch transportn\u00fdch syst\u00e9mov pre lie\u010div\u00e1\u201c<\/em><\/p>\n\n\n\n

Zodpovedn\u00fd rie\u0161ite\u013e aktivity: doc. RNDr. Miroslava Martinkov\u00e1, PhD.<\/em><\/p>\n\n\n\n

Anot\u00e1cia projektu:<\/em> Hlavn\u00fdm cie\u013eom tejto aktivity je v\u00fdvoj novej gener\u00e1cie fotocitliv\u00fdch, biologicky \u00fa\u010dinn\u00fdch sfingoz\u00ednov a biokompaktibiln\u00fdch nosi\u010dov lie\u010div pre personalizovan\u00fa medic\u00ednu. Aktivita sa zaober\u00e1 synt\u00e9zou funkcionalizovan\u00fdch sfingoz\u00ednov a \u0161t\u00fadiom modul\u00e1cie ich biologickej aktivity in vitro<\/em>. Uskuto\u010dn\u00ed sa synt\u00e9za enantiom\u00e9rne \u010dist\u00fdch foriem sfingolipidov, vych\u00e1dzaj\u00fac zo sacharidov\u00fdch chir\u00f3nov. V\u00fdsledn\u00e9 cie\u013eov\u00e9 molekuly bud\u00fa opatren\u00e9 fotocitliv\u00fdmi chr\u00e1niacimi skupinami a azobenz\u00e9nov\u00fdmi prep\u00edna\u010dmi a bud\u00fa podroben\u00e9 biologick\u00e9mu skr\u00edningu na ich protin\u00e1dorov\u00fa aktivitu. \u010eal\u0161ou \u00falohou je kreovanie biokompaktibiln\u00fdch nosi\u010dov lie\u010div na b\u00e1ze oxidu kremi\u010dit\u00e9ho a nanop\u00f3rovit\u00fdch l\u00e1tok typu MOF, ktor\u00e9 s\u00fa schopn\u00e9 prija\u0165 vysok\u00e9 d\u00e1vky lie\u010diva a dopravi\u0165 ho cielene bez jeho pred\u010dasn\u00e9ho uvo\u013enenia.<\/p>\n\n\n\n

<\/p>\n\n\n\n

Spolupr\u00e1ca s praxou, TEHO a.s.<\/em><\/p>\n\n\n\n

N\u00e1zov projektu:<\/em> Synt\u00e9za nov\u00fdch typov antioxidantov<\/strong><\/p>\n\n\n\n

Zodpovedn\u00fd rie\u0161ite\u013e:<\/em> RNDr. J\u00e1n Ele\u010dko, PhD.<\/p>\n\n\n\n

Anot\u00e1cia projektu:<\/em> Synt\u00e9za nov\u00fdch typov organick\u00fdch antioxidantov na ochranu doskov\u00fdch a \u0161pir\u00e1lov\u00fdch tepeln\u00fdch v\u00fdmenn\u00edkov proti zan\u00e1\u0161aniu inkrustov hydrog\u00e9nuhli\u010ditanov\u00e9ho charakteru a monitoring vybran\u00fdch fyzik\u00e1lnochemick\u00fdch parametrov nap\u00e1jac\u00edch a kotlov\u00fdch v\u00f4d cez anal\u00fdzu i\u00f3nov, ktor\u00e9 maj\u00fa vplyv na kvalitu teplej \u00fa\u017eitkovej vody a v\u00fdrobu tepla v plynov\u00fdch kotolniach a odovzd\u00e1vac\u00edch staniciach tepla. Cie\u013eom projektu je minimalizova\u0165 straty pri distrib\u00facii tepla a zamedzi\u0165 vzniku stavu, kedy m\u00f4\u017ee d\u00f4js\u0165 ku poruch\u00e1m na distribu\u010dnom syst\u00e9me a jeho jednotliv\u00fdch komponentoch.<\/p>\n","protected":false},"excerpt":{"rendered":"

VEGA 1\/0375\/19 N\u00e1zov projektu: Stereoselekt\u00edvna synt\u00e9za fotoakt\u00edvnych molek\u00fal s pyrolid\u00ednov\u00fdmi farmakof\u00f3rmi na b\u00e1ze broussonet\u00ednov, oxazolomyc\u00ednov a laktacyst\u00ednu Zodpovedn\u00fd rie\u0161ite\u013e: RNDr. M\u00e1ria Vilkov\u00e1, PhD., doc. RNDr. Miroslava Martinkov\u00e1, PhD. Anot\u00e1cia projektu: Projekt sa zaober\u00e1 stereoselekt\u00edvnou synt\u00e9zou fotoakt\u00edvnych molek\u00fal so zabudovan\u00fdmi pyrolid\u00ednov\u00fdmi farmakof\u00f3rmi na b\u00e1ze boussonet\u00ednov, oxazolomyc\u00ednov a laktacyst\u00ednu. Inkorporovan\u00e9 azobenz\u00e9nov\u00e9 prep\u00edna\u010de a fotocitliv\u00e9 chr\u00e1niace skupiny umo\u017enia mo\u017enos\u0165 cielenej zmeny ich … <\/p>\n

Pokra\u010dova\u0165 v \u010d\u00edtan\u00ed „V\u00fdznamn\u00e9 projekty“<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages\/265"}],"collection":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=265"}],"version-history":[{"count":0,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages\/265\/revisions"}],"wp:attachment":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=265"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}