{"id":49,"date":"2021-02-03T12:16:40","date_gmt":"2021-02-03T11:16:40","guid":{"rendered":"http:\/\/127.0.0.1\/wordpress\/?page_id=49"},"modified":"2021-08-02T12:50:46","modified_gmt":"2021-08-02T10:50:46","slug":"vyskum","status":"publish","type":"page","link":"https:\/\/organicchemistry.science.upjs.sk\/?page_id=49","title":{"rendered":"V\u00fdskum"},"content":{"rendered":"\n<p><em>Vedeck\u00e9 smerovanie Katedry organickej ch\u00e9mie je s\u00fastreden\u00e9:<\/em><\/p>\n\n\n\n<ul><li>na&nbsp;cielen\u00fa a efekt\u00edvnu synt\u00e9zu pestrej palety pr\u00edrodn\u00fdch l\u00e1tok a&nbsp;ich anal\u00f3gov (sfingoin\u00e9 b\u00e1zy, iminosacharidy, aminocyklitoly, spiro-lat\u00e1m-lakt\u00f3nov\u00e9 syst\u00e9my), v&nbsp;r\u00e1mci ktorej s\u00fa vyu\u017eit\u00e9 jednak mo\u017enosti <em>chiral-pool<\/em> strat\u00e9gie a&nbsp;jednak asymetrickej katal\u00fdzy s&nbsp;aplik\u00e1ciou nov\u00fdch bifunk\u010dn\u00fdch tiomo\u010dovinov\u00fdch organokatal\u00fdzatorov. Pozornos\u0165 je s\u00fastreden\u00e1 aj na <em>in vitro<\/em> modulovanie biologickej aktivity pripraven\u00fdch molek\u00fal implement\u00e1ciou molekulov\u00fdch prep\u00edna\u010dov na b\u00e1ze \u0161trukt\u00farne modifikovan\u00fdch azobenz\u00e9nov. V\u00fdsledn\u00e9 \u0161trukt\u00fary s\u00fa podroben\u00e9 biologick\u00e9mu skr\u00edningu so zameran\u00edm sa na protirakovinov\u00fd potenci\u00e1l a&nbsp;inhibi\u010dn\u00fa glykozid\u00e1zov\u00fa aktivitu.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"689\" height=\"298\" src=\"https:\/\/organicchemistry.science.upjs.sk\/wp-content\/uploads\/2021\/04\/untitled.bmp\" alt=\"\" class=\"wp-image-360\" srcset=\"https:\/\/organicchemistry.science.upjs.sk\/wp-content\/uploads\/2021\/04\/untitled.bmp 689w, https:\/\/organicchemistry.science.upjs.sk\/wp-content\/uploads\/2021\/04\/untitled-300x130.jpg 300w\" sizes=\"(max-width: 689px) 100vw, 689px\" \/><\/figure>\n\n\n\n<ul><li>na synt\u00e9zu nov\u00fdch monom\u00e9rnych, homodim\u00e9rnych a&nbsp;heterodim\u00e9rnych deriv\u00e1tov na b\u00e1ze antrac\u00e9nu, akrid\u00ednu, takr\u00ednu, chinol\u00ednu a kumar\u00ednu s o\u010dak\u00e1vanou multifunk\u010dnou \u00fa\u010dinnos\u0165ou vo\u010di Alzheimerovej chorobe (inhib\u00edtory acetylchol\u00ednester\u00e1zy) a&nbsp;antiprolifera\u010dnou aktivitou.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"683\" height=\"386\" src=\"https:\/\/organicchemistry.science.upjs.sk\/wp-content\/uploads\/2021\/04\/untitled1.bmp\" alt=\"\" class=\"wp-image-361\" srcset=\"https:\/\/organicchemistry.science.upjs.sk\/wp-content\/uploads\/2021\/04\/untitled1.bmp 683w, https:\/\/organicchemistry.science.upjs.sk\/wp-content\/uploads\/2021\/04\/untitled1-300x170.jpg 300w\" sizes=\"(max-width: 683px) 100vw, 683px\" \/><\/figure>\n\n\n\n<ul><li>na&nbsp;vypracovanie efekt\u00edvnych synt\u00e9z nov\u00fdch anal\u00f3gov pr\u00edrodn\u00fdch fytoalex\u00ednov s modifikovan\u00fdm indolov\u00fdm skeletom. U cie\u013eov\u00fdch molek\u00fal je overovan\u00e1 ich protirakovinov\u00e1 a&nbsp;antimikrobi\u00e1lna aktivita.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"515\" height=\"225\" src=\"https:\/\/organicchemistry.science.upjs.sk\/wp-content\/uploads\/2021\/04\/untitled2.bmp\" alt=\"\" class=\"wp-image-362\" srcset=\"https:\/\/organicchemistry.science.upjs.sk\/wp-content\/uploads\/2021\/04\/untitled2.bmp 515w, https:\/\/organicchemistry.science.upjs.sk\/wp-content\/uploads\/2021\/04\/untitled2-300x131.jpg 300w\" sizes=\"(max-width: 515px) 100vw, 515px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Vedeck\u00e9 smerovanie Katedry organickej ch\u00e9mie je s\u00fastreden\u00e9: na&nbsp;cielen\u00fa a efekt\u00edvnu synt\u00e9zu pestrej palety pr\u00edrodn\u00fdch l\u00e1tok a&nbsp;ich anal\u00f3gov (sfingoin\u00e9 b\u00e1zy, iminosacharidy, aminocyklitoly, spiro-lat\u00e1m-lakt\u00f3nov\u00e9 syst\u00e9my), v&nbsp;r\u00e1mci ktorej s\u00fa vyu\u017eit\u00e9 jednak mo\u017enosti chiral-pool strat\u00e9gie a&nbsp;jednak asymetrickej katal\u00fdzy s&nbsp;aplik\u00e1ciou nov\u00fdch bifunk\u010dn\u00fdch tiomo\u010dovinov\u00fdch organokatal\u00fdzatorov. Pozornos\u0165 je s\u00fastreden\u00e1 aj na in vitro modulovanie biologickej aktivity pripraven\u00fdch molek\u00fal implement\u00e1ciou molekulov\u00fdch prep\u00edna\u010dov na &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/organicchemistry.science.upjs.sk\/?page_id=49\" class=\"more-link\">Pokra\u010dova\u0165 v \u010d\u00edtan\u00ed<span class=\"screen-reader-text\"> &#8222;V\u00fdskum&#8220;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages\/49"}],"collection":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=49"}],"version-history":[{"count":3,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages\/49\/revisions"}],"predecessor-version":[{"id":542,"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=\/wp\/v2\/pages\/49\/revisions\/542"}],"wp:attachment":[{"href":"https:\/\/organicchemistry.science.upjs.sk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=49"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}